Invited Speakers

Prof. Jung Kyoon Choi

 Senior Research Scientist, Genome Institute of Singapore

 Assistant Professor, Dept. Bio and Brain Engineering, KAIST, Korea




Biosketch: The aim of Prof. Jung’s work is to discover novel knowledge that is buried under a wealth of biological informationby applying computational or statistical methods to whole-genome genetic, epigenetic, and transcriptional data, hoping for valuable discoveries that can increase human health.

His recent interests include but are not limited to:

- Chromatin regulation of RNA splicing: How exonic enrichment of positioned nucleosomes, histone modifications, and DNA methylation influences RNA splicing regulation with the involvement of RNA-binding proteins

- Whole-genome landscape of DNA repair histones: To explore the genomic distribution of the DNA repair histone and its modification in response to DNA damage

- Genetic analysis of chromatin structure: Genetic analysis of open chromatin (chromatin QTL) is expected to provide insight into regulatory variation observed among individuals with different genetic backgrounds

- Genomic analysis of histone structural perturbations: How the amino-acid substitutions of histone proteins influence gene transcription and nucleosome assembly

- Neurogenomics: Genome-wide association analysis offers great opportunities to study neurological disorders by harnessing the power of population genetic analysis.

Prof. Sanghyuk Lee

Director, Korean Bioinformation Center (KOBIC), Korea

Director, Ewha Research Center for Systems Biology (ERCSB)

Div. of Molecular & Life Sciences, Ewha Womans University, Korea

Dr. Onami Shuichi

Team Leader

Developmental Systems Modeling Team

Computational Systems Biology Research Group

 Advanced Computational Sciences Department

RIKEN Advanced Science Institute

Biosketch: The Onami laboratory studies the principles of development and function of multicellular systems. Development of multicellular organism is a spatially and temporally dynamic process. A single cell, the fertilized egg, divides many times to generate many functionally different cells, each of which is brought to a specific position to produce complex multicellular structures, i.e. organs and the body. An effective approach to such spatially and temporally dynamic processes is quantitative and computational approach, which combines quantification, modeling and computer simulation. To understand the mechanism of development of multicellular organisms, we are developing mathematical models of developmental systems, such as C. elegans embryo, by combining molecular cell biology, biophysics, genome science, computational science and mathematical science.

Dr. Takahashi Koichi

Team Leader

Biochemical Simulation Research Team Computational Systems Biology Research Group

Advanced Computational Sciences Department

RIKEN Advanced Science Institute

Biosketch: Dr. Takahashi Koichi is the team Leader (Principal Investigator) of Biochemical Simulation Research Team in RIKEN Advanced Science Institute, Japan. His research interests span every technological areas relevant to cell modeling and simulation, and include effects of non-idealistic nature of intracellular media on signaling pathways,single cell measurement techniques such as correlation spectroscopy, asynchronous discrete event simulation algorithms, and high-performance computing. From 2005 to 2008, he was a Human Frontier Science Program (HFSP) Cross-Disciplinary Fellow at the Molecular Sciences Institute, Berkeley, California. He is a founding steering committee member of the E-Cell Project, and is the creator / chief system architect of the cellular simulation platform E-Cell System.

Prof. Hsien-Da Huang

Chairman of Department of Biological Science & Technology

Institute of Bioinformatics and Systems Biology

National Chiao Tung University, Taiwan

Biosketch: Prof. Hsien-Da Huang’s research areas are in:

  • Metabolic Engineering for glycerol fermentation and ethanol production
  • Reconstructing Gene Regulatory Network
  • Identifying Gene Regulatory Sites
  • Alternative Splicing
  • MicroRNA and sRNA Regulation
  • Regulatory motif finder
  • Identifying Protein Phosphorylation Sites
  • Protein Identification
  • Presenting Protein Structural Properties

Prof. Ueng-Cheng Yang

Principal Investigator

Institute of Biomedical Informatics

National Yang-Ming University, Taiwan


Dr. Ding Chunming

Director and Principal Investigator
Epigenetics Centre
Growth, Development and Metabolism Programme
Singapore Institute for Clinical Sciences


Biosketch: Dr. Ding is currently a principal investigator and the director for epigenetics centre at the Singapore Institute for Clinical Sciences. He was an assistant professor in the Faculty of Medicine at the Chinese University of Hong Kong from 2005-2008, and a research assistant professor in the Bioinformatics program at Boston University from 2003-2004. He has pioneered a number of technologies for sensitive, specific and quantitative analyses of DNA and RNA, and has successfully applied them in non-invasive prenatal diagnosis, cancer monitoring, and pathogen analysis. His work has resulted in numerous publications in prestigious journals such as Science, Nature Medicine, Nature Biotechnology and PNAS with over 900 citations, and over 60 patent applications (2 granted).

Dr. Christopher Hogue

Associate Professor

Department of Biological Sciences, National University of Singapore

Department of Biochemistry, University of Toronto Scientist

Samuel Lunenfeld Research Institute, Toronto


Biosketch: Dr Hogue is a founding full-time member of MBI and supports the computational biology infrastructure of the group. Formerly at the University of Toronto, Dr Hogue was the Principal Investigator who developed the Biomolecular Interaction Network Database. BIND is recognised as the first and most complete molecular interaction database of its kind. The intellectual property behind his research – including BIND and over a million lines of source code – was acquired by Thomson Scientific, making him the first grant recipient to successfully commercialise research work resulting from a Genome Canada investment. A self-taught software developer and architect, he did his Postdoctoral training at NCBI. Highly cited with over 50 peer reviewed papers and over 5000 citations, he has an ongoing academic interest in computational and wet-lab research.

Prof. Patrice Koehl

Associate Professor

UC Davis Genome Center Department of Computer Science College of Engineering

Department of Biological Sciences

National University of Singapore

Biosketch: Prof. Koehl’s research program focus on understanding macromolecular structures. His group is interested in characterizing their shapes, and use this information to improve our understanding of their stability. He is also interested in characterizing the subset of sequence space compatible with a protein or nucleic acid structure: this is an indirect approach to understanding sequence evolution, both at the RNA and protein level. In parallel, the researc members are involved in the development of new algorithms for predicting the structure of a protein, based on its sequence.

Some of his current projects:

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